eNeurobiología - Revista electrónica

 

 

Minerva Ortiz-Valladares¹, Claudia A. Salcedo¹, Mirelta Regalado Ortega¹, Carmen Torrero Solorio¹, Manuel Salas Alvarado¹*

¹Department of Developmental Neurobiology and Neurophysiology, Institute of Neurobiology, National Autonomous University of Mexico, Campus UNAM Juriquilla Querétaro, Mexico.

 

Abstract

Early food restriction resulted in long-term consequences on physical and brain development. However, long-term skeletal maturity parameters interacting with sensory deprivation are scarcely described. We compare the effects of gestational undernutrition and postnatal ligature (UL) and neonatal undernutrition by using an incubator (UI) with sensory deprivation on the physical development of suckling and adult F1 female and male Wistar rats. UL F0 subjects were submitted to caloric food restriction during the gestational period and suckling of dams, one with nipple-ligated and interchanged every 12 h. UI subjects were underfed by placing pups into one incubator for 12 h. Skull, nose-coccyx, tail, tarsus-metatarsus, phalange lengths, bitemporal axis, body weight, mean body sizes and eyelid opening were measured on postnatal days (PDs) 5-90. UL and UI subjects resulted with significant skeletal deficits following a normocaloric diet from PD 25 in most of the ages from PDs 5 to 90 of the study compared with their controls. Furthermore, significant low body weights in both female and male UL groups throughout the lactation period, compared to normally feeding rats were obtained. Body Mass Index (BMI) on PD 90 in female UI subjects showed higher percentages than controls. The findings indicated that gestational undernutrition of F0 dams resulted in consistent, long-term altered physical development of F1 subjects that might interfere with their body growth, sensorimotor activity and possibly with the late social adaptive responses.

Keywords: Early undernutrition, Physical development, Rats, Sensory manipulation, Growth.

 

*Corresponding Author at: Department of Developmental Neurobiology and Neurophysiology, Institute of Neurobiology, Universidad Nacional Autónoma de México, Campus UNAM Juriquilla, Querétaro, Qro. México. Telephone number: 52 (55) 5623 40 59, (442) 238 10 59, Fax number: +52 (55) 56234005. E-mail: masal@unam.mx

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