eNeurobiología - Revista electrónica

 

 

Jorge Manzo^1*, Genaro A. Coria-Avila¹, Luis I. García¹, Maria Elena Hernández¹, Deissy Herrera-Covarrubias¹, Rebeca Toledo¹, Daniela Monje-Reyna^1,2, Fidel Santamaria²

¹Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico, ²Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA

 

Resumen

We studied the sexual behavior and prostate histology in a male rat model of autism. Autistic males displayed every known parameter of mating but most of them not at normal levels. Patterns indicated decreased motivational states and a reduced potency for penile erection and ejaculation, suggesting alterations in central and autonomic pathways. The histology of the prostate revealed dysplasia and anisokaryosis, indicating a possible risk of cancer development. While sexual behavior and reproductive physiology are present in rats with induced autism, the execution relies on inadequate behaviors and several alterations that could result in infertility and prostate cancer.

Keywords: Penile erection, Ejaculation, Prostate cancer, Infertility, Valproic acid.

 

*Corresponding Author at: Centro de Investigaciones Cerebrales. Universidad Veracruzana. Xalapa, Ver. Mexico. C.P. 91010, Tel: 52 (228) 8 418900 ext. 16309. E-mail: jmanzo@uv.mx

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