eNeurobiología - Revista electrónica

 

 

Stephany Esmaile Campanelli¹, Jaerdyson Medeiros da Rocha¹, Jonas Ivan Nobre Oliveira¹

¹Departamento de Biofísica e Farmacologia do Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN - Brasil

 

Resumen

Introduction: The present systematic review aims to analyze articles between 2011 and 2017 that describe the involvement of epigenetic and molecular mechanisms associated with extinction of fear memory. Methods: Inclusion and exclusion criteria were considered to filter the final articles extracted from Science Direct, Pubmed and Google Scholar. Results: From a total of 461 articles, 13 attended the criteria and were displayed in a table divided into: Objective, Brain region, techniques and reference. These final articles were critically analyzed and compared between each other. Discussion: Analysis of drug efficiency and molecular mechanisms involved in extinction and/or consolidation of fear memory in mice and rats may elucidate and thus contribute in the treatment of obsessive-compulsive disorder, anxiety, phobia, panic and posttraumatic stress disorder.

Palabras clave: Memory extinction, Molecular, Epigenetic, Systematic review.

 

*Correspondencia: Departamento de Biofísica e Farmacologia, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Caixa Postal 1524, 59078-970, Natal, RN, Brazil. Tel.: +55(84)98188-6488. E-mail: sce.neuroscience@gmail.com

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